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Other flavonoids activate Nrf2 pathway includes procyanidin,147 apigenin,148 and chrysin.149 Overall, the effects of flavonoids on the Nrf2/ARE pathway appear to be cell typespecific, concentration dependent, and stage dependent and may vary depending on cancer properties

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The poor permeability of anti-TB drugs within granulomas, coupled with ineffective regulation of extracellular signaling, allows M.tb to adapt and develop drug resistance