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1 Introduction Cholesterol is an organic compound classified within the steroid family, characterized by its distinctive chemical structure: four fused hydrocarbon rings, which provide the molecule with extreme rigidity, a proximal hydrophilic hydroxyl (-OH) group at the 3-position, and a distal hydrophobic hydrocarbon tail extending from the 17-position ( Figure 1A ) ( Figure 1 Cholesterol and its derivatives, including cholesterol esters and oxysterols, play several critical roles in cancer progression ( in vitro assays, comparing them to clinically relevant therapeutic doses to provide a more accurate perspective of their potential impact on cancer treatment

Such data would enable precision targeting of pathogenic DCs in autoimmune and tumor contexts

Currently, the receptors targeting DAMPs are not only limited in diversity but also predominantly derived PRRs, which substantially hinders mechanistic investigations of both aseptic inflammation and the pathogenesis of inflammatory diseases

These include the proper activation of mechanisms for plant defense and heavy metal detoxification

The connection between serum zinc and CVD has been explored in several studies