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That's selection bias, not pharmacology

For Pyridoxal-5-Phosphate (PLP, Sigma) supplementation-based growth kinetics, minimal medium (0.5 g/litre asparagine, 1 g/litre KH 2 PO 4 , 2.5 g/litre Na 2 HPO 4 , 50 mg/litre ferric ammonium citrate, 0.5 g/litre MgSO 4 .7H 2 O, 0.5 mg/litre CaCl 2 , and 0.1 mg/litre ZnSO 4 ) containing 0.1% glycerol (vol/vol) was used with or without 50 g/ml PLP (Sigma) supplementation

However, leucine was increased, but its catabolic intermediates (2-hydroxyisocarpoic acid and 3-hydroxy-3-methylglutaric acid) were decreased, possibly reflecting that leucine is needed alone for some purpose

Familial multiple lipomatosis and angiolipomas have been previously discussed including why pain develops in angiolipomas

Research Square Preprint2021 Jan