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Furthermore, the supplementation of energy substrates, including glucose and lactate, significantly augments the energy supply of cells under hypoxic conditions, thereby ensuring the sustained maintenance of normal cellular functions and metabolic homeostasis

This property of IGF-1R also implicates the function of this receptor in tumour progression since the degree of anchorage independency reflects the level of malignancy

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Peptides are more selective

Brain Res 1036:16 Giordano G, Kavanagh TJ, Costa LG (2009) Mouse cerebellar astrocytes protect cerebellar granule neurons against toxicity of the polybrominated diphenyl ether (PBDE) mixture DE-71