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We utilize fruit fly genetics for discovery and then apply in vivo imaging, biophysical approaches, mass spectrometry, metabolomics and high throughput sequencing to explore function

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an antigen is ALPP and/or ALPPL2, and/or a domain of ALPP and/or ALPPL2 bound by M25ADLF, M25ADLFEG, M25ADLFDS, M25FYIA, M25FYIAEG, M25FYIADS M25, M25EG, M25DS, M25AELF, M25AELFEG, M25AELFDS, M25ADL99P M25ADL99G, M25ADS95R, M25ADD28G, M25ADS91G, M25ADY93H, M25ADYHSRLF, M25GRITSGFYGDwtLC, M25FSITSGFYGDwtLC, M253018IA, M253018LF, M25AD, M25ADX, ALPPL2rd3_l, ALPPL2rd3_2, M25AGIA, M25AGLF, M25ASIA, M25ASLF, M25ASwt, M25AVIA, M25AVLF, M25ALIA, M25ALLF, M25wtIA, and/or M25wtLF, e.g., as presented on a cell (e.g., an ALPPL2 positive cancer cell)

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Symptom Management: Our focus is on controlling pain and heavy bleeding rather than curing the condition

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BER enzymes are primarily targeted at removing N7-MeG and N3-MeA lesions, subsequently repairing the DNA through the collaborative action of DNA polymerase and DNA ligase, thus restoring the DNA strand to its original, non-damaged state [165]

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