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4.3 Hypoxia and angiogenesis Uncontrolled division of breast cancer cells often outgrows their blood supply, creating hypoxic conditions (low oxygen level)

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Isatin ( 16 ), (+) - kavain ( 17 ), lapachol ( 18 ), Lawsone ( 19 ), juglone ( 20 ), menadione ( 21 ), 2-methoxy-1,4-naphthoquinone ( 22 ) and 1,4-naphthoquinone ( 23 ) as well as the reference inhibitor, chrysin, were obtained from Sigma-Aldrich