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Of significance, there is growing evidence that the reversible formation of mixed disulfides between GSH and low-pKa cysteinyl residues of proteins ( S -glutathionylation) is an important mechanism for dynamic, posttranslational regulation of a variety of regulatory, structural, and metabolic proteins, and for the regulation of signaling and metabolic pathways in intact cell systems (Dalle-Donne et al., 2007

10.1161/circresaha.122.321667 [DOI] [PMC free article] [PubMed] [Google Scholar] Schieber M, Chandel NS (2014) ROS function in redox signaling and oxidative stress

As such, secretory trafficking not only plays a role in synaptic function, but it also underlies neuronal differentiation and spine morphogenesis, with previous studies demonstrating that the manipulation of proteins involved in regulated secretory trafficking [11, 28, 29] or manipulations that block secretory trafficking [30] result in decreased dendritic outgrowth and impaired neuronal differentiation and spine morphogenesis

non-radical species such as H 2 O 2 and ozone (O 3 ) are also common in plants