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How Creatine Stability Works To really understand this, lets break down the science in simple terms

Nature 444:847853 Coelho M, Oliveira T, Fernandes R (2013) Biochemistry of adipose tissue: an endocrine organ

10.3389/fphar.2019.00382 [DOI] [PMC free article] [PubMed] [Google Scholar] 236.Dai G, Vaughn S, Zhang Y, Wang ET, Garcia-Cardena G, Gimbrone MA

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This difference likely indicates that cystine starvation constitutes a more severe perturbation of cellular cysteine homeostasis than pharmacological inhibition of system x c - by erastin2 or glutamate, leading to a more rapid and extensive depletion of the intracellular cysteine pool