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Mitochondria produce ROS during adenosine triphosphate (ATP) generation, with some electrons leaking from the electron transport chain (ETC), which subsequently leads to superoxide anion production [66]

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( d ) BrdU incorporation (left) and % relative survival (right) in cells transduced with shRNA targeting IDH1 (n = 3 technical replicates representative from 3 independent experiments in each cell line)

J Hum Genet 55(9):565 Xiong D-K, Chen H-H, Ding X-P, Zhang S-H, Zhang J-H (2015) Association of polymorphisms in glutathione S-transferase genes (GSTM1, GSTT1, GSTP1) with idiopathic azoospermia or oligospermia in Sichuan