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(2001) Effect of synthetic pineal tetrapeptide (Ala-Glu-Asp-Gly) on melatonin secretion by the pineal gland of young and old rats [PMID: 11335898, Anisimov VN et al

This is because it can help stimulate endogenous testosterone (natural testosterone) production

Oral routes are associated with delayed or inconsistent systemic effects, depending on molecular size, chemical modification, and formulation

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That would help patients with treatment-resistant insomnia, patients in structured opioid withdrawal programs, and potentially patients with narcolepsy who have not responded to standard medications