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Moreover, dietary supplementation with TMAO significantly decreased the expression of both enteral cholesterol transporters Niemann-Pick C1-like1 (Npc1L1), which transports cholesterol into enterocytes from the intestinal lumen, and ABCG5/8, which transports cholesterol out of enterocytes into the gut lumen ( The TMA/FMO3/TMAO pathway driven by gut microbiota is also an important regulator of lipid metabolism (Warrier et al., 2015)

Yes, high levels of TMAO may turn out to be a key risk factor, but we need more research

Laron, Z Antibodies to islet cell autoantigens, rotaviruses and/or enteroviruses in cord blood and healthy mothers in relation to the 2010-2011 winter viral seasons in Israel: a pilot study Diabet Med 31 6: 681-5

doi: 10.1016/j.eplepsyres.2020.106444 78 Myette-Ct.St-PierreV.BeaulieuS.CastellanoC.-A.FortierM.PlourdeM.et al

Within the context of MCTs, the glycerol backbone provides for three stereochemically distinct FA positions: the two outer positions, known as sn-1 and sn-3 , and the central one, denoted as sn-2 (Zarevcka and Wimmer 2008)