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To test whether any of the genes in the downregulated putative phage locus might act as a repressor of biofilm formation, with that repression potentially being relieved by LCA, we also generated deletion mutants lacking different segments of this locus (leaving intact a predicted bacterial gene on the opposite strand in the middle of the locus, whose expression was unaffected by LCA)

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Differences in -EC accumulation may therefore explain the differences between the studies of Creissen et al

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However, under zinc excess, lysosomal destabilization and leakage of cathepsin D into the cytosol can trigger mitochondrial damage and apoptosis via the lysosomemitochondria axis 168