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Description
Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing

Ye Q, He X-O, DUrzo A (2017) A review on the safety and efficacy of inhaled corticosteroids in the management of asthma

doi: 10.1080/07315724.2017.1386140
This explains the long persistence of the H 2 O 2 molecule in the beta cell and maximizes the chance to be converted to the highly toxic HO at sites all over the beta cell, in particular when H 2 O 2 meets weakly complexed iron (II) ions (Halliwell and Gutteridge 2015

The knockout was verified by staining with fluorescently conjugated anti-CD44 antibodies, ensuring complete receptor deletion for downstream functional assays
