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A seminal study published in Science demonstrated that plasma from exercised aged mice transfers enhanced adult hippocampal neurogenesis and cognition to sedentary aged recipients, identifying the liver enzyme GPLD1 as a key mediator whose systemic elevation recapitulates these benefits without entering the brain [32]

10.1210/en.2011-1586 114 SchwartzM

These observations further illustrate that it is challenging to compare health claims just based on colorimetric assays commonly used for reporting antioxidant activities in foods

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Additionally, estrogen promotes a gynoid pattern of fat distribution, characterized by fat accumulation in the hips and thighs, which is associated with lower metabolic risk compared to abdominal (android) fat distribution