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However, it is largely ineffective, with ascorbate triggering AHA in erythrocytes

Diminished level of intracellular glutathione has been associated with immune dysfunction (T cell activation, imbalance Th1/Th2 cytokines and deregulation of apoptosis) and organ damage (nephritis, CNS) in SLE [20, 70, 71]

Recent Advances in Bioinorganic Chemistry of Bismuth

Although astrocyte reactivity serves as an initial defensive mechanism, excessive or prolonged reactivity has been implicated in the progression of neurodegenerative diseases

H3R antagonists such as ciproxifan have also been effective in enhancing alertness and memory [60], alleviating repetitive behavior in VPA-exposed mice [62], and correcting aberrant histamine-modulated neural activity in the cortico-basal ganglia circuitry [63,64] (Figure 1)