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J., Cai, W

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The pathological process of cardiac remodeling, which involves alterations in the structure and function of the heart, is a major way that TMAO aggravates these effects [77]

doi: 10.1038/nature05414

In addition to the upregulation of macrophage scavenger receptors potentially contributing to enhanced forward cholesterol transport 10 , we show that TMAO, and its dietary precursors choline and carnitine, suppress reverse cholesterol transport through gut microbiota-dependent mechanisms in vivo