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Description
NNMT inhibition reduces consumption of nicotinamide (and of S-adenosylmethionine) by blocking the enzyme that would otherwise methylate them
If sciatic nerve damage occurs, medical attention is necessary to assess the severity of the injury and determine appropriate treatment options

It has an hepatic metabolism, mainly because of the glucuro-conjugation of the molecule, with the formation of inactive metabolites
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It inhibits NNMT, an enzyme that methylates nicotinamide (a precursor to NAD+)
