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Attribution to specific NOX sources benefits from O 2 readouts by DHE-HPLC (especially for NOX2) and from compartment-targeted, genetically encoded H 2 O 2 sensors such as HyPer variants that can be directed to the plasma membrane, endosomes, or nucleus to resolve isoform- and location-specific signaling with appropriate pharmacologic and genetic controls (Cipriano et al

For example, IL-2 treatment has been shown to increase Treg numbers and reduce inflammation in COPD models (123)

Biomarkers such as CYP370A13 expression, glutathione depletion, and oxidative stress serve as sensitive indicators of APAP exposure

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Second, it inhibits aromatase, the enzyme that converts testosterone to estrogen