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2021;16(2) doi: 10.1371/journal.pone.0246952
Phenytoin is metabolized in the liver by parahydroxylation
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High levels of the transcription factor NRF2 can induce metabolic reprogramming in dormant tumor cells, re-establishing redox homeostasis and de novo synthesis of nucleotides, accelerating the activation of tumor cells and tumor recurrence
