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This pathway is typically activated downstream of death receptors such as tumor necrosis factor receptor 1 (TNFR1) upon binding of ligands like tumor necrosis factor-alpha (TNF-), especially when apoptotic pathways are inhibited, for example, through caspase-8 inactivation (91)

Due to the fragile and deformable nature of the spinal cord, hydrogels that are too hard cannot be used to treat SCI

Metabolic B12 deficiency is prevalent, impacting 10%-40% of the population

Apart from collagen degradation owing to excessive MMP expression, ROS also triggers a decrease in collagen production by inhibiting the TGF- signal pathway (75)

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