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Mechanistic Comparison# Dosing Comparison# Amycretin Dosing# Amycretin dosing is investigational: Subcutaneous: Once-weekly injection, doses up to 60 mg studied in phase 1b/2a over 36 weeks Oral: Daily tablet, doses up to 50 mg (or 2 x 50 mg) studied in phase 1 Phase 2 T2D: Both subcutaneous and oral formulations studied over 36 weeks Phase 3 dose selection will be informed by the completed phase 2 data

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This accounts for 4 weeks at each dose level: (2x4) + (4x4) + (8x4) + (12x4) = 8 + 16 + 32 + 48 = 104mg

Consistency: Using the same, appropriate type of syringe for every application ensures that any minuscule systemic error is at least consistent, rather than random and chaotic

When relying on removable media, the system should have no significant nonvolatile memory components which could contain unauthorized information remaining within the system