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Cys 2 ) and cystine-free (Cys 2 -free) medium with vehicle (DMSO) or RSL3 (250 nM), alone or with Fer-1 (10 M) or Trolox (100 M)

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Broad gene-mapping work led by Pickart and colleagues reported modulation of thousands of genes, with roughly a third of human gene patterns shifting toward expression states associated with younger or healthier tissue