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By facilitating their passage through gastrointestinal barriers, enhancing transmembrane absorption, and optimizing transport kinetics, lipid nanoparticles (LNPs) dramatically increase the bioavailability of medications with restricted permeability

Impairment of the intestinal barrier facilitates the translocation of detrimental substances, including endotoxins and bacterial metabolites, into the systemic circulation

doi: 10.1186/s42269-020-00466-x

it has been found that PKA decreased the phosphorylation of p38MAPK in ESCs [82]