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Although CYP2B6 also contributes to the metabolism of sertraline, the impact of CYP2C19 is significantly more pronounced (Yan et al., 2025)

The GM metabolite TMAO inhibited Cytotoxicity through activation of the nuclear receptors Farnesoid X receptor (FXR) and small heterodimer partner (SHP) to inhibit the expression of Cyp7a1, an enzyme that plays a key role in cholesterol metabolism and bile acid synthesis, reducing hepatic BA synthesis, accelerating the development of AS, and decreasing reverse cholesterol transport [61], providing further evidence of the link between gut microbiota and AS (Table 1)

Conversely, fasting blood glucose, fasting blood insulin, and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) did not change significantly after six weeks of watermelon puree supplementation [24]

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