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Consequently, any therapeutic considerations in this context should be approached with caution, and further well-documented clinical observations and controlled studies would be necessary before drawing conclusions regarding the efficacy or safety of potential treatment modalities

Ti-EV DNA showed a higher frequency of mutant alleles when compared with the total plasma DNA, indicating the potential value of Ti-EVs as melanoma biomarkers (Crescitelli et al

Starting doses typically range from 0.20.5 mg