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Epub 2016/05/04

It is known that reduction in CD38 expression on BM and circulating MM cells occurs rapidly after daratumumab initiation with significantly lower expression levels after the first infusion compared with baseline (potentially due to elimination of MM cells with high CD38 levels, endocytosis, or release in microvesicles), that may persist for at least 6 months after discontinuation [35]

Additionally, water-soluble dendrimers can be prepared, in contrast to most polymers, via functionalizing the external shell with the help of hydrophilic groups or charged species

Funding This study was supported by National Science and Technology Major Projects for Major New Drugs Innovation and Development (No

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