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It has also been shown that aldo-keto reductase family 1 member B1 (AKR1B1) interacts with signal transducer and activator of transcription 3 (STAT3) to up-regulate SLC7A11, which leads to increased Cys 2 uptake in lung cancer cell lines and xenograft mouse models, and further promotes lung cancer cell resistance [80]

For example, MMP-9, produced by both AECs and Thy-1-negative fibroblasts, not only activates TGF- to sustain a profibrotic cycle but also enhances fibroblast migration and collagen deposition (Kobayashi et al., 2014), thereby contributing to abnormal alveolar bronchiolization

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