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Higgins JPT, Thomas J, Chandler J et al (2021) Cochrane handbook for systematic reviews of interventions version 6.2 Sterne JAC, Savovi J, Page MJ et al (2019) RoB 2: a revised tool for assessing risk of bias in randomized trials

Supplements are especially suitable for people with impaired gastrointestinal absorption, such as older adults, individuals who have undergone stomach or intestinal surgery, or those who follow a vegetarian or vegan diet

There are other reasons such as iron deficiency and thyroid dysfunction that may lead to symptoms similar to sub-optimal B12 levels

Researchers often study this compound pairing to better understand how signaling mechanisms interact with metabolic efficiency in controlled laboratory environments