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Whereas cardiomyocyte hyperplasia brought about by increased microcirculatory blood supply (e.g., during pregnancy, growth, or when undergoing athletic training) is considered physiological and perfectly reversible, adverse or pathological remodeling following myocardial infarction (MI) is associated with disproportionate risk for heart failure (HF) and carries significant worse survival [42]

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En ciertas condiciones fisiolgicas, por ejemplo, al hacer ejercicio, los msculos necesitan mayor aporte de sangre por lo que se estimulan ciertas clulas cardiacas para aumentar la frecuencia cardiaca y as aportar mayor flujo sanguneo