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[DOI] [PubMed] [Google Scholar] 105.Cao DJ, Wang ZV, Battiprolu PK, Jiang N, Morales CR, Kong Y, Rothermel BA, Gillette TG, Hill JA

Commonly, intercurrent or common infections will cause onset of symptoms in previously asymptomatic individuals

Prescher M, Kroll T, Schmitt L

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Research indicates that niacinamide formulations optimized at neutral pH may enhance efficacy in darker skin phototypes where enhanced permeation facilitates superior melanin transfer inhibition, making it particularly suitable for Indian dermatological practice where melasma prevalence ranges from 8-40% in certain populations