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This shuttle predominates in the liver, heart, and kidneys

The only differences with a p-value less then 0.01 were lower RBC copper (-9% lower, p = 0.001) and higher plasma methionine sulfoxide (+35% higher, p = 0.002) for the autism medication group compared to the autism no-medication group

10.1016/j.intimp.2021.107728 249 YoonG.KimY
Indeed, given the low levels of labile copper in the cytoplasm, cuproenzymes require copper chaperones to transport copper from the plasma membrane to their intracellular locations

doi: 10.1258/phleb.2007.007061
