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N Engl J Med 2016;375:255060

However, our current knowledge of immune cell metabolism mostly comes from studies in vitro and animal models, and its applicability to humans needs further validation

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The brain shows only limited gluconeogenesis mediated by astrocytes, possibly using the very low levels of either mitochondrial phosphoenolpyruvate carboxykinase 2 (PCK2) or cytoplasmic PCK1 (Yip et al., 2016)

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