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Deficiency after gastric banding is therefore primarily related to: Reduced dietary intake and food tolerance , limiting consumption of B12-rich foods Use of acid-suppressing medicines (PPIs or H2RAs) , which can impair the release of B12 from food proteins and reduce absorption of food-bound B12 Crystalline B12 the form found in supplements and fortified foods does not require acid or pepsin for release

Convenient Treatment Sessions Sessions are typically short, lasting around 15 to 30 minutes, allowing patients to integrate therapy into a busy schedule

Statistical testing between groups is a way of assessing whether any differences occur by chance, but if randomisation has been performed correctly then any differences in baseline characteristics between the treatment groups in an RCT are, by definition, due to chance [29]

In addition, it may be necessary to consider two pharmacodynamic variables: maximum effect attainable in the target tissue and the sensitivity of the tissue to the drug