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In the rat model of induced IVD degeneration via artificial annular tears, 60 subsequent nerve sprouting following disc degeneration highly correlated to grip strength impairment was observed, most likely mediated by axial hypersensitivity
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The differing effects of vanin-1s downstream products have created ambiguity regarding its involvement in various diseases, particularly as research has predominantly focused on the vanin-1/cysteamine pathway while neglecting the vanin-1/PA axis (Fig
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