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This enzyme catalyzes the N-methylation of nicotinamide using S-adenosyl-L-methionine (SAM) as a methyl donor, effectively creating a "metabolic drain" that depletes both NAD+ precursors and cellular methylation capacity

Suppliers sell the reference standard as an iodide salt, and the literature describes it as a selective NNMT inhibitor with an IC50 near 1.2 micromolar, meaning it shuts the enzyme down at low concentrations without hitting related enzymes

WARNINGS: In the prevention and treatment of megaloblastic anemia, the combination of this product and folic acid can achieve better results