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Its GIP receptor binding is actually the most potent of the three pathways, with an EC50 of 0.0643 nM compared to 0.775 nM for GLP-1

The Neelakantan 2018 paper showed strong oral absorption in cell uptake (Caco-2) assays, which is why most research community use is by mouth instead of by injection

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While BPC 157 exhibits a favorable profile, systemic peptide administration is a significant physiological intervention

Some studies have suggested that rapid improvements in glycemic control with semaglutide may be associated with temporary worsening of diabetic retinopathy in certain patients, particularly those with pre-existing retinopathy