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Only after clearing all these hurdles can a company file a New Drug Application (NDA)
The other is that BosR remains bound to RNAP-RpoS, but ligand-bound PlzA negates BosRs transactivator effect on RNAP-RpoS
20 BrozP
New aspects of the blood-brain barrier transporters
Drug Discovery Ther (2015) 9(1):3844
