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Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer

Briefly, the authors developed a stable clone by transfecting MCF7 cells with the cDNA of human cytosolic GPx1

Mutation of Glu521 or Glu535 in cytoplasmic loop 5 causes differential misfolding in multiple domains of multidrug and organic anion transporter MRP1 (ABCC1)

The suitability of each compound for ISF versus blood-based sensing is thus determined largely by its molecular size, hydrophobicity, and binding characteristics