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Naltrexone, approved in 1984, introduced a non-opioid antagonist that blocked the effects of opioids but required full detoxification before initiation, limiting its early use
1997 May-Oct;91(3-5):113-22
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Jeraj R, Harris J, Rosenthal DI , Nguyen-Tan PF, Axelrod R, Schwartz DJ, Sherman VE, Galvin JM, Cuna E, Min Y, Trotti A, Garden AS, Beitler JJ, Thorstad WL, Jones CU, Zhang Q, Le QT, Xiao Y

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