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Possible Side Effects Side effects are uncommon but may include mild soreness at the injection site or a temporary headache

Nava Mesa, B Vitamins in the nervous system: Current knowledge of the biochemical modes of action and synergies of thiamine, pyridoxine, and cobalamin, CNS Neurosci

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B12 deficiency is widespread, but should be of special concern when on a plant-based diet

This enzyme catalyzes the N-methylation of nicotinamide using S-adenosyl-L-methionine (SAM) as a methyl donor, effectively creating a "metabolic drain" that depletes both NAD+ precursors and cellular methylation capacity