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An in-solution digestion protocol was performed as detailed previously ( Raw data processing The mass spectrometric raw data were processed and analyzed using MaxQuant software (version 1.4.7.2) (Szklarczyk et al., 2015), the statistical environment R and Perseus (Tyanova et al., 2016)

( A ) Lung metastatic cell lines (PDAC) stably expressing wild-type ipCW- Gstt1 were treated with doxycycline for 5 days, lysed and subjected to immunoprecipitation using a Gstt1 antibody (whole cell lysate)

score 3 (moderate), multiple small foci or several large foci

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