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TDP-43 aggregation induced by oxidative stress causes global mitochondrial imbalance in ALS
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25 DKK-1/3/4 prevent canonical Wnt signalling by binding to LRP5/6 or further forming a tertiary complex with the single transmembrane receptors Kremen 1 and 2, which induce the endocytosis of LRP5/6

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Prog Neuropsychopharmacol Biol Psychiatry 79:340
