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Supporting this, Lebouvier et al

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secondly, relative to other organs, the brain has lower levels of ROS scavenging enzymes and thirdly the brain is 60% fat a high proportion of which is unsaturated fatty acids that are highly susceptible to lipid peroxidation

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In animal studies of intervertebral disc degeneration, cell-based therapeutic strategies have shown that injecting mesenchymal stem cells (MSCs) into the nucleus pulposus can allow them to survive for months and induce ECM production