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Dai J, Su Y, Zhong S, Cong L, Liu B, Yang J, et al

These results clearly indicate that after failure of PD-(L)1 inhibitor therapy, nab-paclitaxel not only improved ORR but also achieved a durable response rate of 13% in patients with advanced NSCLC, with toxicity reactions within an acceptable range [119]

(iii) safety/nanotoxicology

This M2-TGF--Smad-FPN1 axis underscores how immunosuppressive macrophages shape the TME to protect cancer cells from ferroptosis, emphasizing the need to target M2 polarization alongside ferroptosis induction for effective immunomodulation, thereby desensitizing cancer cells to ferroptosis inducers

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