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In contrast, HIF-1 protein levels did not peak in human cells until 1 h in hypoxia, and HIF-1 abundance declined continuously following this peak

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In mice and rats, tirzepatide caused a dose-dependent and treatment-duration-dependent increase in the incidence of thyroid C-cell tumors (adenomas and carcinomas) after lifetime exposure at clinically relevant plasma exposures

In SURMOUNT-1, adults with obesity or overweight without diabetes were randomized to tirzepatide or placebo for 72 weeks

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