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Most research is preclinical or small

The absence or overexpression of Piezo1 leads to abnormalities in the organism, such as hippocampal dysfunction (Xiong et al., 2022), cavernous cerebral malformation (Scimone et al., 2022), peritumoral brain edema (Qu et al., 2020a), and CNS demyelination (Velasco-Estevez et al., 2020)

The peptides that dominate the wellness and biohacking conversation are largely not FDA-approved drugs