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In ovaries, it seems that CSE must be silenced upon malignant transformation, since it is expressed in normal epithelial ovarian cells but it is absent in malignant tumors ( 2 S production, which activates cancer cells proliferation and migration, through ROS/PI3K/AKT/mTOR and MAPK pathways ( Cysteine degradation catalyzed by CAT and MST (Figure 1B) is not deeply explored in cancer, since MST is more enzymatically efficient at a pH higher than the physiological, thus the role of CBS and CSE is considered more relevant in cancer biology ( 2 S from N-acetylcysteine instead of cysteine-derived 3-mercaptopyruvate

10.1074/mcp.M900325-MCP200 38 FrovaC

One magnetic resonance spectroscopy study suggested that abnormal cerebral glucose metabolism was correlated with abnormal values of N-acetyl-aspartate (NAA) normalized to creatine (NAA/Cr) in brain regions associated with cognition (40)

MOTS-C correlates with muscle strength indices and has been found to increase exercise performance in mice by increasing glycolysis rate and ATP concentration

American College of Surgeons Clinical Congress 2022, 2022
