swanson glutathione precursor complex L-Glutathione Page 1 - Reviews -

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doi: 10.3389/fnagi.2026.1835649 Received 21 March 2026 Revised 04 May 2026 Accepted 07 May 2026 Published 29 May 2026 Volume 18 - 2026 Edited by Ruosha Lai, Central South University, China Reviewed by Qingwei Ruan, Fudan University, China Emily Fabrizio-Stover, Medical University of South Carolina, United States Updates Copyright 2026 Liu and Liu

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Conclusion This RCT provides evidence to show that GlyNAC supplementation in OA improves GSH deficiency, OxS, mitochondrial impairment, mitophagy, inflammation, insulin resistance, endothelial dysfunction, physical function and strength, exercise capacity, waist circumference, state systolic blood pressure, and multiple hallmarks of aging (mitochondrial dysfunction, altered intercellular communication, dysregulated nutrient sensing, loss of proteostasis, genomic toxicity, stem-cell exhaustion, and cellular senescence)