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Increased NEFAs in cells compete with glucose for substrate oxidation, thus resulting in the inhibition of pyruvate dehydrogenase, phosphofructokinase, and hexokinase II [8]
doi: 10.1007/s11695-016-2449-9
This fact is relevant as transgenic mice overexpressing IGFBP-2 were resistant to developing obesity when fed with high fat diet [174], suggesting that this molecule could have a direct effect on preadipocyte differentiation
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