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PLoS Pathog 6:e1000902
It also has documented activity at CD36, a scavenger receptor involved in fatty acid uptake and inflammatory signaling
In resting cells, a high ratio of AMP to ATP leads to elevated AMPK activity and diminished mTOR function
Certain types of cancer, including renal cell carcinoma, hematologic malignancies, glioblastoma, pancreatic cancer, and those reported to depend on HIF-2, seem to depend on glutamine
